Berberine Chloride Supplementation Ameliorates Excessive Hepatic Lipid Deposition and Proinflammatory Gene Upregulation in the Soybean-Oil-Based Diet of Juvenile Yellow Drum (Nibea albiflora)

In this study, we fed yellow drum juveniles (initial body weigh 5.57 ± 0.03 g) a fish-oil-based, soybean-oil-based (SO), or berberine chloride (BBR 50 mg kg-1 in SO-based diet) diet with three replicates of each treatment for 56 days. Dietary BBR supplementation significantly increased growth performance but decreased SO-induced viscerosomatic index and condition factor increases. Hepatic tissue Oil Red O staining indicated that completely compensated the excessive lipid deposition. resulted significant decrease saturated fatty acids increase proportion n-6 polyunsaturated hepatic tissue. RNA sequencing revealed amelioration deposition by could be attributed to an acid ?-oxidation. also proinflammatory gene expression, characterized suppression cytokine–cytokine receptor interaction pathway. Collectively, our findings demonstrated beneficial effects dietary on performance, deposition, expression. The is likely caused ?-oxidation, which promotes energy production growth.